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Type 5 reactions (presumed T-cell cytotoxity) are not well described, may take longer than 72 hours, and often result in a maculopapular rash. Shorter, faster thrusts are what lead to a faster orgasm in men. Isosorbide Dinitrate, ISDN: (Moderate) Rare and sometimes fatal cases of methemoglobinemia have been reported with the use of topical or oromucosal benzocaine products... Link Details